Oxidative Stress and Inflammation in Diabetic Complications

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Oxidative Stress and Inflammation in Diabetic Complications

1 Department of Internal Medicine, Carver College of Medicine, University of Iowa, IA 52246, USA 2Centre for Translational Cancer Research, IBT, Texas A&M HSC, Houston, TX 77030, USA 3Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hyderabad, Andhra Pradesh 500037, India 4Centre for Genetic Diseases and Molecular Medicine, Central Universi...

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Oxidative stress and diabetic complications.

Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium. This increased superoxide production causes the activation of 5 major pathways involved in the pathogene...

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The Relationship between Inflammation, Oxidative Stress, and Metabolic Risk Factors in Type 2 Diabetic Patients

Abstract Objective: Globally, 3-5.2 percent of people suffer from diabetes which is one of the most serious metabolic disorders resulting in an increase in inflammatory biomarkers e.g. interleukin-6, tumor necrosis factor-alpha, and C-reactive protein. The aim of this study was to investigate the relationship between inflammation, oxidative stress and fasting blood glucose, lipid profile and a...

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Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro

Objective(s): Naringin, an essential flavonoid, inhibits inflammatory response and oxidative stress in diabetes. However, whether naringin has beneficial effects on diabetic retinopathy (DR) remains unknown. Materials and Methods: Streptozotocin (STZ, 65 mg/kg) was intraperitoneally injected into male rats (8 weeks old weighting 200-250 g) to establish diabetic model, then naringin (20, 40 or 8...

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Dalteparin as a Novel Therapeutic Agent to Prevent Diabetic Encephalopathy by Targeting Oxidative Stress and Inflammation

Introduction: Hepcidin is the principal modulator of systemic iron metabolism, and its role in the brain has been clarified recently. Studies have shown hepcidin plays an important role for in neuronal iron load and inflammation. This is of significance because neuronal iron load and inflammation are pathophysiological processes that have been highly linked to neurodegeneration. Moreover, the a...

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ژورنال

عنوان ژورنال: International Journal of Endocrinology

سال: 2014

ISSN: 1687-8337,1687-8345

DOI: 10.1155/2014/679754